Uroplakin Peptide-Specific Autoimmunity Initiates Interstitial Cystitis/Painful Bladder Syndrome in Mice
نویسندگان
چکیده
منابع مشابه
Uroplakin Peptide-Specific Autoimmunity Initiates Interstitial Cystitis/Painful Bladder Syndrome in Mice
The pathophysiology of interstitial cystitis/painful bladder syndrome (IC/PBS) is enigmatic. Autoimmunity and impaired urothelium might lead the underlying pathology. A major shortcoming in IC/PBS research has been the lack of an appropriate animal model. In this study, we show that the bladder specific uroplakin 3A-derived immunogenic peptide UPK3A 65-84, which contains the binding motif for I...
متن کاملThe role of TSG-6 and uroplakin III in bladder pain syndrome/ interstitial cystitis in rats and humans
Objective(s):We investigated the relationship between the expression of tumor necrosis factor-inducible gene 6 (TSG-6) with inflammation and integrity of the bladder epithelium in the bladder tissues of patients with bladder pain syndrome/interstitial cystitis (BPS/IC) and the mechanism of action using a rat model of BPS/IC. Materials and Methods: Expression of TSG-6 and uroplakin III was det...
متن کاملThe role of TSG-6 and uroplakin III in bladder pain syndrome/ interstitial cystitis in rats and humans
Objectives We investigated the relationship between the expression of tumor necrosis factor-inducible gene 6 (TSG-6) with inflammation and integrity of the bladder epithelium in the bladder tissues of patients with bladder pain syndrome/interstitial cystitis (BPS/IC) and the mechanism of action using a rat model of BPS/IC. Materials and Methods Expression of TSG-6 and uroplakin III was determ...
متن کاملBladder Pain Syndrome/Interstitial cystitis:
Background BPS/IC is a chronic syndrome with bladder pain, divided into two main types: one with so called Hunner`s lesions (classic type) and one without (nonulcer type). In the recently presented ESSIC classification system the classic type, in focus of the present work, has the designation Type 3C BPS/IC. Symptoms are characterized by bladder pain, urgency, frequency and nocturia. The aetiol...
متن کاملInterstitial cystitis/painful bladder syndrome.
Interstitial cystitis/painful bladder syndrome affects more than 1 million persons in the United States, but the cause remains unknown. Most patients with interstitial cystitis/painful bladder syndrome are women with symptoms of suprapubic pelvic and/or genital area pain, dyspareunia, urinary urgency and frequency, and nocturia. It is important to exclude other conditions such as infections. Te...
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ژورنال
عنوان ژورنال: PLoS ONE
سال: 2013
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0072067